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L9536 Sigma

Anti-Leptin Receptor antibody produced in goat

affinity isolated antibody, lyophilized powder

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Obesity Research, Antibodies to Hormones,
species reactivity   mouse
application(s)   flow cytometry: suitable
  immunohistochemistry (frozen sections): suitable
  western blot: suitable
clone   polyclonal
antibody form   affinity isolated antibody
form   lyophilized powder
storage temp.   −20°C
Gene Information   mouse ... Lepr(16847)
biological source   goat
conjugate   unconjugated

Description

Immunogen

recombinant mouse leptin receptor expressed in NS0 cells.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Biochem/physiol Actions

Leptin is a hormone secreted by adipocytes and regulates energy homeostasis, inflammation and neuroendocrine processes, synaptic formation and memory condensation. The physiological effects of leptin are mediated by leptin receptors, ObR and LepR. Leptin is the key regulator of obesity and acts directly on neuronal networks to regulate feeding, metabolism, gastric mobility and energy homeostasis. The pathways that mediate the effect of leptin are JAK/STAT, PI3K and JNK.

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