L9656 Sigma

Lipoprotein Lipase from Burkholderia sp.

lyophilized powder, ≥50,000 units/mg solid

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Synonym: Diacylglycerol acylhydrolase, Diacylglycerol lipase, Lipoprotein Lipase from Pseudomonas sp.

Description

General description

Lipoprotein lipase hydrolyzes triglycerides in plasma lipoproteins causing release of fatty acids for metabolic purposes in muscles and adipose tissue. 4

Unit Definition

One unit will release 1.0 nmole of p-nitrophenol per min at pH 7.2 at 37 °C using p-nitrophenyl butyrate as substrate.

Application

Lipoprotein lipase has been used in a study to assess the role of lipogenic enzymes in colorectal cancer. 1 It has also been used in a study to investigate lipasemic activity of low molecular weight heparin in rats. 2

Biochem/physiol Actions

Due to its lipolytic activity, lipoprotein lipase was shown to effectively block the spread of hepatitis C virus into healthy cells. 3

Lipoprotein lipase belongs to the family of triglyceride lipases. It hydrolyses triglycerides in triglyceride-rich ApoB-containing lipoproteins.

Price and Availability

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