Synonym: Diacylglycerol acylhydrolase, Diacylglycerol lipase, Lipoprotein Lipase from Pseudomonas sp.
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Lipoprotein lipase hydrolyzes triglycerides in plasma lipoproteins causing release of fatty acids for metabolic purposes in muscles and adipose tissue. 4
One unit will release 1.0 nmole of p-nitrophenol per min at pH 7.2 at 37 °C using p-nitrophenyl butyrate as substrate.
Lipoprotein lipase has been used in a study to assess the role of lipogenic enzymes in colorectal cancer. 1 It has also been used in a study to investigate lipasemic activity of low molecular weight heparin in rats. 2
Due to its lipolytic activity, lipoprotein lipase was shown to effectively block the spread of hepatitis C virus into healthy cells. 3
Lipoprotein lipase belongs to the family of triglyceride lipases. It hydrolyses triglycerides in triglyceride-rich ApoB-containing lipoproteins.
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lyophilized powder, 25-75 units/mg protein
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4. Inactivation of lipoprotein lipase occurs on the surface of THP-1 macrophages where oligomers of angiopoietin-like protein 4 are formed Makoveichuk, E., et al. Biochem. Biophys. Res. Commun. 425, 138-42, (2012)
Subcellular Distribution Of Okadaic Acid In The Digestive Gland Of Mytilus Galloprovincialis: First Evidences Of Lipoprotein Binding To Okadaic Acid. Rossignoli, A.E., et al. Toxicon 55, 221-6, (2010)
Gain-of-function lipoprotein lipase variant rs13702 modulates lipid traits through disruption of a microRNA-410 seed site. Richardson K, Nettleton JA, Rotllan N, et al. Am. J. Hum. Genet. 92(1), 5-14, (2013)
Insulin effect on lipogenesis and fat distribution in three genotypes of ducks during overfeeding. Gontier K, André JM, Bernadet MD, et al. Comp. Biochem. Physiol. A. Mol. Integr. Physiol. 164(3), 499-505, (2013)
Endothelial heparanase regulates heart metabolism by stimulating lipoprotein lipase secretion from cardiomyocytes. Wang Y, Zhang D, Chiu AP, et al. Arterioscler. Thromb. Vasc. Biol. 33(5), 894-902, (2013)
Molecular cloning and transcript expression of genes encoding two types of lipoprotein lipase in the ovary of cutthroat trout, Oncorhynchus clarki. Ryu YW, Tanaka R, Kasahara A, et al. Zoolog. Sci. 30(3), 224-37, (2013)
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