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L9783
Sigma
Leupeptin hydrochloride
microbial, ≥90% (HPLC)
DOWNLOAD MSDS (PDF)Synonym:
Acetyl-
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CAS Number 24125-16-4
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Empirical Formula (Hill Notation) C20H38N6O4 · HCl
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Molecular Weight 463.01
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MDL number MFCD00133457
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PubChem Substance ID 24896529
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Popular Documents: Product Information Sheet (PDF)
Properties
| Related Categories | Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Core Bioreagents, Enzyme Inhibitors, |
| biological source | microbial |
| assay | ≥90% (HPLC) |
| storage temp. | −20°C |
Description
Analysis Note
Leupeptin gives multiple peaks on HPLC due to equilibria among three forms in solution. Purity determined using three main peaks. Majority of contaminating peptide is racemized leupeptin.
Biochem/physiol Actions
Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM. There have been numerous studies using leupeptin to protect against hearing loss caused by acoustic overstimulation or the ototoxic antibiotic gentamicin.1 (Loss of cochlear hair cells is believed to be mediated by calpain.)
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