LY-294,002 hydrochloride solid, ≥98% (HPLC)

Properties

Related Categories	Autophagy, Autophagy Inhibitors, Bioactive Small Molecules, Biochemicals and Reagents, Cancer Research, Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Inositol Phosphates, Kinase/Phosphatase Biology, L, Lipids in Cell Signaling, P to Q, PI3K-Akt-mTOR Enzyme Regulators, Phosphatidylinositol 3-kinase, Phosphatidylinositol 3-kinase (PI3K), Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors, Small Molecules for Stem Cell Biology, Stem Cell Biology, Tumor Growth Regulation More...
assay	≥98% (HPLC)
form	solid
color	white to off-white
solubility	DMSO: >5 mg/mL
	H₂O: insoluble
storage temp.	2-8°C

Description

Frequently Asked Questions

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Biochem/physiol Actions

Specific cell permeable phosphatidylinositol 3-kinase inhibitor.

Price and Availability

Related Papers

A specific inhibitor of phosphatidylinositol 3-kinase 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). Vlahos, C.J., et al. J. Biol. Chem. 269, 5241, (1994)

Documents

Certificate of Analysis

Certificate of Origin

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Celltransmissions 19(2) (158 KB )

Celltransmissions 19(2) (260 KB )

Phosphoinositide Kinases (129 KB )

Safety Information

Personal Protective Equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
WGK Germany	3

Technical information & documentation associated with this product is available in the Safety & Documentation tab.

Articles

Autophagy in Cancer Promotes Therapeutic Resistance

Autophagy is a highly regulated process by which long-lived proteins, organelles, and protein aggregates are captured within autophagosomes, which are then fused with lysosomes for degradation.1 Auto...
Linda Stephenson, Ph.D., Product Specialist, Sigma^® Life Science
Biofiles, Vol. 8, No. 9
Keywords: Apoptosis, Autophagy, Cancer, Degradations, Metabolites, transformation

Oncogenes and Tumor Suppressors Reprogram Metabolism

Proliferating cells require the biosynthesis of structural components for biomass production and for genomic replication. This requires a reprogramming of the metabolic pathways to ensure nutrients s...
Keywords: Aerobic, Antitumor agents, Apoptosis, Cancer, Degradations, Environmental, Gene expression, Glycolysis, Growth factors, Metabolic Pathways, Metabolism, Metabolites, Nucleotide Synthesis, PAGE, Pentose phosphate pathway, Phosphorylations