Anti-LRRK2 (C-terminal region) antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution
DOWNLOAD MSDS (PDF)Synonym: Anti-AURA17, Anti-Dardarin, Anti-Leucine-rich repeat protein kinase 2, Anti-PARK8, Anti-RIPK7, Anti-ROCO2
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Properties
| Related Categories | Alphabetical Index, Antibodies, Antibodies for Parkinson’s Disease Research, Antibodies in Array, Cell Biology, |
| species reactivity | mouse, rat, human |
| application(s) | western blot: 2-4 μg/mL using HEK-293T cells expressing human LRRK2, and using rat and mouse brain extracts (S2 fraction) |
| clone | polyclonal |
| concentration | ~1.0 mg/mL |
| antibody form | affinity isolated antibody |
| form | buffered aqueous solution |
| mol wt | antigen mol wt ~240 kDa |
| shipped in | dry ice |
| storage temp. | −20°C |
| Gene Information |
human ... LRRK2(120892) mouse ... Lrrk2(66725) rat ... Lrrk2(300160) |
Description
Immunogen
synthetic peptide corresponding to amino acids 2079-2100 of human LRRK2 conjugated to KLH. The corresponding sequence is highly conserved (single amino acid substitution) in mouse and rat LRRK2.
General description
LRRK2 is a μLtimeric kinase that also functions as a GTPase. LRRK2 activates a CaMKK-β/AMPK signaling pathway and subsequently mediates autophagy. Genetic alterations in LRRK2 cause late-onset Parkinson′s disease 1,2. Anti-LRRK2 (C-terminal region) antibody is specific for LRRK2 (approx. 240 kDa) in mice, rats and humans. Staining of the LRRK2 band by immunoblotting is specifically inhibited by the LRRK2 immunizing peptide.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Application
Anti-LRRK2 (C-terminal region) antibody is suitable for use in western blot (2-4 μg/mL using HEK-293T cells expressing human LRRK2, and using S2 fractions of rat and mouse brain extracts).
Price and Availability
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