L -Mimosine from Koa hoale seeds
≥98%
DOWNLOAD MSDS (PDF)Synonym: (S)-α-Amino-β-[1-(3-hydroxy-4-oxopyridine)]propionic acid, Leucenol
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CAS Number 500-44-7
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Empirical Formula (Hill Notation) C8H10N2O4
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Molecular Weight 198.18
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EC Number 207-905-1
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MDL number MFCD00075909
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PubChem Substance ID 24896541
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Popular Documents: FTIR (PDF)
Properties
| Related Categories | Aerobic Glycolysis (the Warburg Effect), Apoptosis and Cell Cycle, Bioactive Small Molecules, Cancer Metabolism, Cancer Research, |
| assay | ≥98% |
Description
Biochem/physiol Actions
L-Mimosine is a plant amino acid and potential inhibitor of the cell cycle giving rise to growth arrest in G1-phase. An iron chelator that inhibits DNA replication in mammalian cells. Has been shown to have apoptotic activity in xenotransplanted human pancreatic cancer. L-Mimosine is also used as a hypoxia-mimetic agent to stabilize Hypoxia Inducible Factor 1 (HIF-1). L-Mimosine stabilizes HIF-1 through the inhibition of Prolyl Hydroxylases (PHDs) which target HIF-1 through degradation. The mechanism of inhibition is likely through the chelation of Fe2+ bound to the active site of PHD which is required for enzymatic activity.
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