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M0267 Sigma

(±)-Methadone hydrochloride

powder, ≥98% (TLC)

Synonym: 6-Dimethylamino-4,4-diphenylheptan-3-one hydrochloride


Related Categories Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents, Calcium Channel Modulators, Cell Biology,
assay   ≥98% (TLC)
form   powder
drug control   USDEA Schedule II; Home Office Schedule 2; stupéfiant; kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada
color   white to off-white
solubility   H2O: >50 mg/mL, clear, colorless to yellow


Biochem/physiol Actions

μ opioid receptor agonist that desensitizes both the μ opioid receptor and the δ opioid receptor on chronic exposure; narcotic analgesic, characterized by a gradual onset of action and prolonged, milder withdrawal; may also block L-type calcium channels independently of its effects on opioid receptors.

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Price and Availability

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98 atom % D, 1 mg/mL in methanol, drug standard

European Pharmacopoeia (EP)

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