Mitomycin C from Streptomyces caespitosus

Papers

Design, synthesis, and in vitro evaluation of dipeptide-based antibody minor groove binder conjugates. Scott C Jeffrey et al J. Med. Chem. 48, 1344-58, (2005)

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Cytotoxic activity of some natural and synthetic guaianolides. Maurizio Bruno et al J. Nat. Prod. 68, 1042-6, (2005)

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Cytotoxic clerodane diterpenoids from Casearia membranacea. Ya-Ching Shen et al J. Nat. Prod. 68, 1665-8, (2005)

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Synthesis and biological evaluation of simplified mycothiazole analogues. Graciela Mahler et al Bioorg. Med. Chem. Lett. 16, 1309-11, (2006)

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Novel skeleton terpenes from Celastrus hypoleucus with anti-tumor activities. Kui-wu Wang et al Bioorg. Med. Chem. Lett. 16, 2274-7, (2006)

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Xenicane-type diterpenes with cytotoxicity from Xenia florida. Yuan-Bin Cheng et al J. Nat. Prod. 69, 675-8, (2006)

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Cytotoxic and apoptotic activities of novel amino analogues of boswellic acids. Bhahwal A Shah et al Bioorg. Med. Chem. Lett. 17, 6411-6, (2007)

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Stereoselective synthesis and cytotoxicity of a cancer chemopreventive naphthoquinone from Tabebuia avellanedae. Mitsuaki Yamashita et al Bioorg. Med. Chem. Lett. 17, 6417-20, (2007)

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Erythrocarpines A-E, new cytotoxic limonoids from Chisocheton erythrocarpus. Khalijah Awang et al Bioorg. Med. Chem. 15, 5997-6002, (2007)

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Lemnalosides A-D, decalin-type bicyclic diterpene glycosides from the marine soft coral Lemnalia sp. Guangmin Yao et al J. Nat. Prod. 70, 901-5, (2007)

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Synthesis and cytotoxic activity of some novel polycyclic gamma-butyrolactones. M P S Ishar et al Bioorg. Med. Chem. Lett. 18, 4809-12, (2008)

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Synthesis, metal ion binding, and biological evaluation of new anticancer 2-(2'-hydroxyphenyl)benzoxazole analogs of UK-1. Mireya L McKee et al Bioorg. Med. Chem. 16, 1775-83, (2008)

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Synthesis of new pyrazolo[5,1-c][1,2,4] benzotriazines, pyrazolo[5,1-c]pyrido[4,3-e][1,2,4] triazines and their open analogues as cytotoxic agents in normoxic and hypoxic conditions. Giovanna Ciciani et al Bioorg. Med. Chem. 16, 9409-19, (2008)

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Novel N-(phosphonomethyl) glycine derivatives: Design, characterization and biological activity. Emilia D Naydenova et al Eur. J. Med. Chem. 43, 1199-205, (2008)

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Synthesis and cytotoxicity evaluation of some benzimidazole-4,7-diones as bioreductive anticancer agents. Armand Gellis et al Eur. J. Med. Chem. 43, 1858-64, (2008)

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Marine natural product libraries for high-throughput screening and rapid drug discovery. Tim S Bugni et al J. Nat. Prod. 71, 1095-8, (2008)

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Cespihypotins Q-V, verticillene diterpenoids from Cespitularia hypotentaculata. Ya-Ching Shen et al J. Nat. Prod. 71, 1993-7, (2008)

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Microwave-assisted synthesis of N-substituted cyclic imides and their evaluation for anticancer and anti-inflammatory activities. Sham M Sondhi et al Bioorg. Med. Chem. Lett. 19, 1534-8, (2009)

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Potent antitumor bifunctional DNA alkylating agents, synthesis and biological activities of 3a-aza-cyclopenta[a]indenes Kakadiya, R., et al. Bioorg. Med. Chem. 17, 5614, (2009)

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Synthesis and evaluation of bioactive naphthoquinones from the Brazilian medicinal plant, Tabebuia avellanedae. Mitsuaki Yamashita et al Bioorg. Med. Chem. 17, 6286-91, (2009)

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New transition metal ion complexes with benzimidazole-5-carboxylic acid hydrazides with antitumor activity. Shadia A Galal et al Eur. J. Med. Chem. 44, 1500-8, (2009)

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Aziridine alkaloids as potential therapeutic agents. Fyaz M D Ismail et al Eur. J. Med. Chem. 44, 3373-87, (2009)

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Possible anticancer agents: QSAR analogs of glutamamide: synthesis and pharmacological activity of 1,5-N,N'-disubstituted-2-(substituted benzenesulphonyl) glutamamides. Soma Samanta et al Eur. J. Med. Chem. 44, 70-82, (2009)

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SOS regulation of qnrB expression. Minghua Wang et al Antimicrob. Agents Chemother. 53, 821-3, (2009)

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Vladimuliecins A and B: cytotoxic pentacyclic pregnanols from Vladimiria muliensis. Jian-Jun Chen et al J. Nat. Prod. 72, 1128-32, (2009)

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New anti-malarial phenylpropanoid conjugated iridoids from Morinda morindoides. Satoru Tamura et al Bioorg. Med. Chem. Lett. 20, 1520-3, (2010)

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Solvent free synthesis, anti-inflammatory and anticancer activity evaluation of tricyclic and tetracyclic benzimidazole derivatives. Sham M Sondhi et al Bioorg. Med. Chem. Lett. 20, 2306-10, (2010)

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Design and synthesis of harzialactone analogues: promising anticancer agents. Vishwas U Pawar et al Bioorg. Med. Chem. Lett. 20, 7243-5, (2010)

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New pterocarpanquinones: synthesis, antineoplasic activity on cultured human malignant cell lines and TNF-alpha modulation in human PBMC cells. Chaquip D Netto et al Bioorg. Med. Chem. 18, 1610-6, (2010)

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Cytotoxic and anti-inflammatory cembranoids from the Dongsha Atoll soft coral Sarcophyton crassocaule. Wan-Yu Lin et al Bioorg. Med. Chem. 18, 1936-41, (2010)

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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Denis Fourches et al Chem. Res. Toxicol. 23, 171-83, (2010)

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QSPR modeling of octanol/water partition coefficient of antineoplastic agents by balance of correlations. Andrey A Toropov et al Eur. J. Med. Chem. 45, 1639-47, (2010)

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Synthesis, pharmacological activity and comparative QSAR modeling of 1,5-N,N'-substituted-2-(substituted naphthalenesulphonyl) glutamamides as possible anticancer agents. Amit Kumar Halder et al Eur. J. Med. Chem. 45, 1760-71, (2010)

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The influence of the aziridinyl substituent of benzimidazoles and benzimidazolequinones on toxicity towards normal and Fanconi anaemia cells. Karen Fahey et al Eur. J. Med. Chem. 45, 1873-9, (2010)

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Synthesis and toxicity towards normal and cancer cell lines of benzimidazolequinones containing fused aromatic rings and 2-aromatic ring substituents E. Moriarty, et al. Eur. J. Med. Chem. 45, 3762-3769, (2010)

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Synthesis, anti-inflammatory and anticancer activity evaluation of some novel acridine derivatives. Sham M Sondhi et al Eur. J. Med. Chem. 45, 555-63, (2010)

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Cytotoxic activity of 3-(5-phenyl-3H-[1,2,4]dithiazol-3-yl)chromen-4-ones and 4-oxo-4H-chromene-3-carbothioic acid N-phenylamides. Tilak Raj et al Eur. J. Med. Chem. 45, 790-4, (2010)

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Terpenoids from the aerial parts of Parasenecio deltophylla. Guo-Du Huang et al J. Nat. Prod. 73, 1954-7, (2010)

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DNA-damaging, mutagenic, and clastogenic activities of gentiopicroside isolated from Cephalaria kotschyi roots. Khuraman Mustafayeva et al J. Nat. Prod. 73, 99-103, (2010)

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Synthesis and in vitro cytotoxic evaluation of N-alkylbromo and N-alkylphthalimido-isatins. Pardeep Singh et al Bioorg. Med. Chem. Lett. 21, 3017-20, (2011)

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2,5-Disubstituted-1,3,4-oxadiazoles/thiadiazole as surface recognition moiety: design and synthesis of novel hydroxamic acid based histone deacetylase inhibitors. Harish Rajak et al Bioorg. Med. Chem. Lett. 21, 5735-8, (2011)

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Crassocolides N-P, three cembranoids from the Formosan soft coral Sarcophyton crassocaule. Guey-Horng Wang et al Bioorg. Med. Chem. Lett. 21, 7201-4, (2011)

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Synthesis and mechanistic studies of a mitomycin dimer containing an eight-membered cyclic disulfide. Hyun Jung Park et al Bioorg. Med. Chem. 19, 4004-13, (2011)

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Biologically active constituents from the fruiting body of Taiwanofungus camphoratus. Li-Shian Shi et al Bioorg. Med. Chem. 19, 677-83, (2011)

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2-Anilinonicotinyl linked 2-aminobenzothiazoles and [1,2,4]triazolo[1,5-b] [1,2,4]benzothiadiazine conjugates as potential mitochondrial apoptotic inducers. Ahmed Kamal et al Bioorg. Med. Chem. 19, 7136-50, (2011)

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FDA-approved drug labeling for the study of drug-induced liver injury. Minjun Chen et al Drug Discov. Today 16, 697-703, (2011)

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Translating Clinical Findings into Knowledge in Drug Safety Evaluation - Drug Induced Liver Injury Prediction System (DILIps). Zhichao Liu et al PLoS Comput. Biol. 7, e1002310, (2011)

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Acyl derivatives of boswellic acids as inhibitors of NF-?B and STATs. Ajay Kumar et al Bioorg. Med. Chem. Lett. 22, 431-5, (2012)

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Synthesis, antiproliferative activity and genotoxicity of novel anthracene-containing aminophosphonates and a new anthracene-derived Schiff base. I Kraicheva et al Bioorg. Med. Chem. 20, 117-24, (2012)

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1,2,3-Triazole tethered ?-lactam-Chalcone bifunctional hybrids: synthesis and anticancer evaluation. Pardeep Singh et al Eur. J. Med. Chem. 47, 594-600, (2012)

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Bakuchiol derivatives as novel and potent cytotoxic agents: A report. Rabiya Majeed et al Eur. J. Med. Chem. 49C, 55-67, (2012)

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Isolation and structure of a covalent cross-link adduct between mitomycin C and DNA. Tomasz, M., et al. Science 235, 1204-1208, (1987)

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Sequence-specific DNA damage induced by reduced mitomycin C and 7-N-(p-hydroxyphenyl)mitomycin C. Ueda, M., et al. Nucleic Acids Res. 12, 6673-6683, (1984)

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Y. Hashimoto et al. Acc. Chem. Res. 17, 403, (1984)

Merck 14,6215