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M0689 Sigma

Myelin Basic Protein Antigen from human brain

≥95% (SDS-PAGE)

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Properties

Related Categories Biochemicals and Reagents, Myelin-Associated Glycoprotein, Proteins and Derivatives, Structural Proteins
assay   ≥95% (SDS-PAGE)
storage temp.   −20°C
Gene Information   human ... MBP(4155)

Description

Biochem/physiol Actions

Determined using polyclonal and monoclonal antibodies against MBP.

Myelin basic protein (MBP) plays a vital role in formation of myelin sheath and is associated with the various neurological disorders. MBP function as an antigenic target in autoimmune disease experimental allergic encephalomyelitis (EAE). It also has a crucial role to play in human demyelinating diseases including multiple sclerosis (MS). MBP plays an essential role in cytoskeletal turnover and membrane extension. Additionally, it is also involved in Fyn-mediated signaling pathways, sequestration of phosphoinositides and regulation of calcium homoeostasis.

Other Notes

Blood samples from donors were tested and found to be negative for HBsAg, HIV-1 and HIV-2 antibodies, HCV.

Physical form

Lyophilized from 10mM HCl.

Application

Myelin basic protein antigen from human brain has been used in enzyme-linked immunosorbent spot assays.

General description

Myelin basic protein (MBP) is an 18.5kDa protein encoded by the gene mapped to human chromosome 18q22qter. MBP is a major component of myelin sheath and is highly expressed in central nervous system (CNS).

Price and Availability

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C

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