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M0800 Sigma

Anti-p38 MAP Kinase antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Kinase/Phosphatase Biology, P-PA,
species reactivity   rat, mouse
application(s)   microarray: suitable
  western blot: 1:10,000 using NIH3T3 mouse fibroblast lysate and rat brain extract
clone   polyclonal
antibody form   IgG fraction of antiserum
form   buffered aqueous solution
mol wt   antigen mol wt 40 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... MAPK1(5594)
mouse ... Mapk1(26413)
rat ... Mapk1(116590)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide K-DEVISFVPPPLDQEEMES derived from the C-terminus of mouse p38 MAP kinase (amino acids 343-360 with N-terminally added lysine) as immunogen. This sequence is highly conserved in human and rat p38 MAP kinase.

General description

P38 MAPK is a mitogen-activated protein kinase (MAPK) that belongs to serine/threonine protein kinases family and is activated in response to stress signals like- osmolarity changes, UV-irradiation, heat shock,cytokines and lipopolysaccharides (LPS). It mainly expresses in brain, muscle, thymus, spleen, heart, lung, kidney and fibroblasts and is required for phosphorylation of MAPK-activated protein kinase 2 (MAPKAPK-2). Anti-p38 MAP Kinase antibody can be used to study the differential tissue expression, specific activation requirements and intracellular localization of MAP kinase isoforms in normal and neoplastic tissues. Rabbit anti-p38 MAP Kinase antibody reacts specifically with p38 MAP kinase from mouse and rat.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Application

Anti-p38 MAP Kinase antibody can be used in western blotting (diluted 1:1000) using using NIH 3T3 mouse fibroblasts cell lysate and rat brain extract. It can also be used in microarray.

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Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  3
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Monoclonal and polyclonal primary antibodies are focused on cell biology, neurobiology and molecular biology. Secondary antibodies targeting multiple host’s IgG are conjugated to alkaline phosphatase...
Keywords: Amplification, Buffers, Cell biology, Enzyme-linked immunosorbent assay, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Molecular biology, Phosphorylations, Purification, Western blot

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