Synonym: MPTP hydrochloride
|Related Categories||Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Dopaminergics, M,|
|drug control||kontrollierte Droge in Deutschland|
|color||white to off-white|
10, 100 mg in serum bottle
Reportedly causes a severe and irreversible Parkinsonian condition in humans and monkeys.
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>97% (titration), powder
≥97% (HPLC), white powder
≥98% (HPLC), solid
Certificate of Analysis
Certificate of Origin
|Hazard statements||H301 + H311 + H331-H315-H319-H335|
|Precautionary statements||P261-P280-P301 + P310-P305 + P351 + P338-P311|
|Hazard Codes (Europe)||T|
|Risk Statements (Europe)||25-36/37/38-39/23/24/25|
|Safety Statements (Europe)||26-39-45|
|RIDADR||UN 2811 6.1 / PGII|
Intracellular Zn2+ accumulation contributes to synaptic failure, mitochondrial depolarization, and cell death in an acute slice oxygen-glucose deprivation model of ischemia. Medvedeva YV, Lin B, Shuttleworth CW, Weiss JH J. Neurosci., 1105-14, (2009)
Effects of repeated systematic administration of methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to mice on interleukin-1β and nerve growth factor in the striatum. Mogi, M., et al. Neurosci. Lett. 250, 25-28, (1998)
A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Burns, R.S., et al. Proc. Natl. Acad. Sci. U. S. A. 80, 4546-4550, (1983)
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