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M105 Sigma

Methoctramine hydrate

≥97% (NMR), solid

Synonym: Methoctramine tetrahydrochloride hydrate, N,N′-bis[6-[[(2-Methoxyphenyl)methyl]amino]hexyl]-1,8-octane diamine tetrahydrochloride hydrate

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Properties

Related Categories Antagonists, Cell Biology, Cell Signaling and Neuroscience, Cholinergics, Neuroscience,
InChI Key   XIIINYPADNNZHA-UHFFFAOYSA-N
assay   ≥97% (NMR)
form   solid
color   white
solubility   H2O: >20 mg/mL
storage temp.   2-8°C
Gene Information   human ... CHRM2(1129)

Description

Biochem/physiol Actions

Methoctramine is a selective M2 muscarinic receptor antagonist at nM concentrations. At mM concentrations, methoctramine directly inhibits the high affinity GTPase activity of G proteins. The increase in calcium and arachidonic acid release were attenuated by the M2 receptor antagonist methoctramine, but not by the M3 receptor antagonist p-fluoro-hexahydro siladifenidol.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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