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M1177 Sigma

Myriocin from Mycelia sterilia

≥98% (HPLC), powder

Synonym: (2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic acid, ISP-I, Thermozymocidin

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Lipids in Cell Signaling,
InChI Key   ZZIKIHCNFWXKDY-GNTQXERDSA-N
assay   ≥98% (HPLC)
form   powder
color   off-white
solubility   methanol: soluble2 mg/mL
storage temp.   2-8°C

Description

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Biochem/physiol Actions

Fungal metabolite with potent immunosuppressant activity. Inhibits serine palmitoyltransferase at picomolar concentrations blocking synthesis of ceramide, a precursor of sphingomyelin and glycosphingolipids. Disrupts substratum adhesion of melanoma cells. It has been suggested that its immunosuppressant activity in the cytotoxic T-cell line CTTL-2 is due to apoptosis induction.

Packaging

5, 25 mg in glass bottle

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Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
RTECS 
JX3890000
Protocols & Articles
Peer-Reviewed Papers
15

References

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