|Related Categories||Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Lipids in Cell Signaling, M,|
|solubility||methanol: soluble2 mg/mL|
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Fungal metabolite with potent immunosuppressant activity. Inhibits serine palmitoyltransferase at picomolar concentrations blocking synthesis of ceramide, a precursor of sphingomyelin and glycosphingolipids. Disrupts substratum adhesion of melanoma cells. It has been suggested that its immunosuppressant activity in the cytotoxic T-cell line CTTL-2 is due to apoptosis induction.
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50 μg/mL in acetonitrile: water, analytical standard, for environmental analysis
sphingosine N-acyltransferase inhibitor
Sigma Grade, ≥99% (TLC), powder
Certificate of Analysis
|Precautionary statements||P301 + P310|
|Personal Protective Equipment||dust mask type N95 (US), Eyeshields, Faceshields, Gloves|
|Hazard Codes (Europe)||Xn|
|Risk Statements (Europe)||22|
|RIDADR||UN 2811 6.1 / PGIII|
The essential structures of ISP-I that influence serine palmitoyltransferase inhibition in Chinese hamster ovary cells. Mizukoshi K, Matsumoto K, Hirose R, et al. Biol. Pharm. Bull. 35(8), 1349-53, (2012)
Myriocin, an inhibitor of serine palmitoyl transferase, impairs the uptake of transferrin and low-density lipoprotein in mammalian cells. Meyer SG, Wendt AE, Scherer M, et al. Arch. Biochem. Biophys. 526(1), 60-8, (2012)
Inhibition of serine palmitoyl transferase I reduces cardiac ceramide levels and increases glycolysis rates following diet-induced insulin resistance. Ussher JR, Folmes CD, Keung W, et al. PLoS ONE 7(5), e37703, (2012)
Inhibition of serine palmitoyltransferase delays the onset of radiation-induced pulmonary fibrosis through the negative regulation of sphingosine kinase-1 expression. Gorshkova I, Zhou T, Mathew B, et al. J. Lipid Res. 53(8), 1553-68, (2012)
Myriocin, a serine palmitoyltransferase inhibitor, suppresses tumor growth in a murine melanoma model by inhibiting de novo sphingolipid synthesis. Lee YS, Choi KM, Lee S, et al. Cancer Biol. Ther. 13(2), 92-100, (2012)
Protein kinase Ypk1 phosphorylates regulatory proteins Orm1 and Orm2 to control sphingolipid homeostasis in Saccharomyces cerevisiae. Roelants FM, Breslow DK, Muir A, et al. Proc. Natl. Acad. Sci. U. S. A. 108(48), 19222-7, (2011)
Lipidomics of Candida albicans biofilms reveals phase-dependent production of phospholipid molecular classes and role for lipid rafts in biofilm formation. Lattif AA, Mukherjee PK, Chandra J, et al. Microbiology 157(Pt 11), 3232-42, (2011)
Cholesterol- and sphingolipid-rich microdomains are essential for microtubule-based membrane protrusions induced by Clostridium difficile transferase (CDT). Schwan C, Nölke T, Kruppke AS, et al. J. Biol. Chem. 286(33), 29356-65, (2011)
Intact sphingomyelin biosynthetic pathway is essential for intracellular transport of influenza virus glycoproteins. Tafesse FG, Sanyal S, Ashour J, et al. Proc. Natl. Acad. Sci. U. S. A. 110(16), 6406-11, (2013)
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