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M1177 Sigma

Myriocin from Mycelia sterilia

≥98% (HPLC), powder

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Synonym: (2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic acid, ISP-I, Thermozymocidin

Myriocin from Mycelia sterilia ≥98% (HPLC), powder
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Properties

Related Categories Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Lipids in Cell Signaling, M,
assay   ≥98% (HPLC)
form   powder
color   off-white
solubility   methanol: soluble2 mg/mL
storage temp.   2-8°C

Description

Biochem/physiol Actions

Fungal metabolite with potent immunosuppressant activity. Inhibits serine palmitoyltransferase at picomolar concentrations blocking synthesis of ceramide, a precursor of sphingomyelin and glycosphingolipids. Disrupts substratum adhesion of melanoma cells. It has been suggested that its immunosuppressant activity in the cytotoxic T-cell line CTTL-2 is due to apoptosis induction.

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