|Related Categories||Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Lipids in Cell Signaling, M,|
|solubility||methanol: soluble2 mg/mL|
Fungal metabolite with potent immunosuppressant activity. Inhibits serine palmitoyltransferase at picomolar concentrations blocking synthesis of ceramide, a precursor of sphingomyelin and glycosphingolipids. Disrupts substratum adhesion of melanoma cells. It has been suggested that its immunosuppressant activity in the cytotoxic T-cell line CTTL-2 is due to apoptosis induction.
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50 μg/mL in acetonitrile: water, analytical standard, for environmental analysis
sphingosine N-acyltransferase inhibitor
Sigma Grade, ≥99% (TLC), powder
Certificate of Analysis
|Precautionary statements||P301 + P310|
|Personal Protective Equipment||dust mask type N95 (US), Eyeshields, Faceshields, Gloves|
|Hazard Codes (Europe)||Xn|
|Risk Statements (Europe)||22|
|RIDADR||UN 2811 6.1/PG 3|
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