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M1390 Sigma

3,3′-Methylene-bis(4-hydroxycoumarin)

Synonym: Bishydroxycoumarin, Dicoumarol, Dicumarol

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Related Categories Biochemicals and Reagents, Cell Biology, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates,
InChI Key   DOBMPNYZJYQDGZ-UHFFFAOYSA-N
mp   290-292 °C(lit.)
Gene Information   human ... CYP2C9(1559)

Description

Packaging

5, 25 g in poly bottle

Biochem/physiol Actions

Prototype of the 4-hydroxycoumarin class of anticoagulants, which act as vitamin K antagonists, preventing formation of prothrombin. There are many reports that dicumarol also inhibits NADPH:quinone oxidoreductase (NQO(1)). In one, it inhibited NQO(1) in a pancreatic cancer cell line, causing increased formation of superoxide and inhibiting cell growth.

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Tissue Diagnostics

All labs need water

Biomedical Applications
Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
RTECS 
GN7875000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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