Synonym: 2-MeSAMP, 2-Methylthio-AMP triethylammonium salt hydrate
|Related Categories||Biochemicals and Reagents, Nucleosides, Nucleotides, Oligonucleotides, Nucleotide Analogs More...|
|solubility||H2O: soluble20 mg/mL, clear, colorless|
The only known preferential antagonist for P2Y(AC) receptor; this is the platelet ADP receptor that is coupled to adenyl cyclase and is also referred to as the P2Y ADP receptor.
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≥89% (HPLC), solid
Once known as P2 purinoreceptors, surface receptors for extracellular nucleotides are now called P2 receptors. This subtle change in nomenclature reflects the more varied nature of nucleotidic ligand...
Arachidonate metabolism, 5-hydroxytryptamine release and aggregation in human platelets activated by palmitaldehyde acetal phosphatidic acid. Brammer, J.P. and Maguire, M.H. Br. J. Pharmacol. 82, 61, (1984)
P2Y12 or P2Y1 inhibitors reduce platelet deposition in a microfluidic model of thrombosis while apyrase lacks efficacy under flow conditions. Maloney SF, Brass LF, Diamond SL. Integr. Biol. (Camb.) 2, 183-192, (2010)
Effects of P2Y1 receptor antagonism on the reactivity of platelets from patients with stable coronary artery disease using aspirin and clopidogrel. Labarthe B, Babin J, Bryckaert M, et al. Br. J. Pharmacol. 166(1), 221-31, (2011)
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