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M1439 Sigma

MIG from mouse

>97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder

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Description

Analysis Note

The biological activity is measured by its ability to chemoattract human lymphocytes cultured in the presence of IL-2 for 8-10 days and by its ability to chemoattract BaF/3 cells transfected with hCXCR3.

Biochem/physiol Actions

MIG, a member of the α (CXC) chemokine family of inflammatory and immunoregulatory cytokines, is a chemoattractant for activated T lymphocytes and TIL, but not for neutrophils or monocytes. The MIG gene is induced in macrophages and primary glial cells of the central nervous system specifically in response to IFN-γ. MIG with large C-terminal deletions have diminished activity in calcium flux assay. The chemokine receptor CXCR3 is specific for MIG and IP-10 and highly expressed in IL-2-activated T-lymphocytes.

Physical form

Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% TFA containing 0.5 mg bovine serum albumin.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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