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M1547 Sigma

Metronidazole

BioXtra

Synonym: 2-Methyl-5-nitroimidazole-1-ethanol

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Properties

Related Categories Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics G-M, Antibiotics by Application,
InChI Key   VAOCPAMSLUNLGC-UHFFFAOYSA-N
product line   BioXtra
impurities   ≤0.0005% Phosphorus (P)
  ≤0.1% Insoluble matter
ign. residue   ≤0.1%
color   white
mp   159-161 °C(lit.)
solubility   acetic acid: soluble0.1 M, clear, colorless to yellow
anion traces   chloride (Cl-): ≤0.05%
  sulfate (SO42-): ≤0.05%
cation traces   Al: ≤0.0005%
  Ca: ≤0.005%
  Cu: ≤0.0005%
  Fe: ≤0.0005%
  K: ≤0.005%
  Mg: ≤0.0005%
  Na: ≤0.01%
  Pb: ≤0.001%
  Zn: ≤0.0005%
Mode of action   DNA synthesis | interferes
antibiotic activity spectrum   Gram-negative bacteria
  parasites
storage temp.   2-8°C

Description

Packaging

5, 25 g in glass bottle

Application

Metronidazole is a nitroimidazole used to treat amebiasis, vaginitis, Trichomonas infections, giardiasis, anaerobic bacteria and treponemal infections. Metronidazole is used to study DNA damage and repair and has been found to induce the gene transfer agent VSH-1 in Brachyspira hyodysenteriae. It is commonly used for treatment of periodontitis and is used in bioavailability studies.

Biochem/physiol Actions

Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce metronidazole to its active form. Reduced metronidazole covalently binds to DNA which disrupts its helical structure, induces DNA strand breaks and inhibits bacterial nucleic acid synthesis. Bacterial cell death results.

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Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
NI5600000
Protocols & Articles
Peer-Reviewed Papers
15

References

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