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M1891 Sigma

Myelin Basic Protein bovine

≥90% (SDS-PAGE), lyophilized powder

Synonym: MBP

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Description

Application

Used as a kinase substrate.

Myelin Basic Protein (MBP) bovine has been used in following studies:
• In vitro methylation reaction.
• Myelin basic protein is used as a substrate in in vitro immunoprecipitation-kinase assay to measure Cds1 (the S-phase-specific checkpoint effector kinase) activity.
• It is used to prepare phosphorylated MBP, which is used as a substrate in phosphatase assays.

Packaging

1, 5, 25 mg in glass bottle

Quality

May contain traces of urea-glycine buffer salts.

Biochem/physiol Actions

Major structural protein of CNS myelin

Mutation of the myelin basic protein gene induces dysmyelination; used to induce experimental allergic encephalomyelitis. Major structural protein of CNS myelin

Myelin basic protein (MBP) plays a vital role in formation of myelin sheath and is associated with the various neurological disorders. MBP functions as an antigenic target in autoimmune disease experimental allergic encephalomyelitis (EAE). MBP plays an essential role in cytoskeletal turnover and membrane extension. Additionally, it is also involved in Fyn-mediated signaling pathways, sequestration of phosphoinositides and regulation of calcium homoeostasis. MBP functions as an in vitro substrate for mitogen-activated protein kinase (MAP) kinase and aids in the purification and functional studies of enzyme.

Price and Availability


Amplified Detection

Making Headway

All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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