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M1919 Sigma

Monoclonal Anti-Macrophages antibody produced in mouse

clone LN-5, ascites fluid



Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Cell and Organelle Proteins, Antibodies to Cellular Antigens,
biological source   mouse
antibody form   ascites fluid
clone   LN-5, monoclonal
contains   15 mM sodium azide
species reactivity   human
application(s)   immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:400 using formalin-fixed, paraffin-embedded human tonsil sections
isotype   IgM
conjugate   unconjugated
shipped in   dry ice
storage temp.   −20°C



deparaffinized human peripheral blood mononuclear cells


The antibody recognizes an antigen present in the cytoplasm of human macrophages in a wide variety of tissues and organs. The epitope recognized is resistant to formalin-fixation and paraffin-embedding. This antibody may also be used on material fixed with B5 solution, neutral buffered formalin, zinc-formalin, Brunnel′s, Susa and Bouin′s solutions but not in standard frozen sections. The antibody stains the cytoplasm of macrophages and histiocytes in hematopoietic organs, Kupffer′s cells of the liver, and Langerhans′ cells of the skin. Mantle zone B lymphocytes and interdigitating reticulum cells of lymph node and B cells in spleen are also stained. Bone marrow lymphoid and myeloid precursor cells stain with a uniform interstitial pattern. Certain normal non-lymphoid cells such as spermatogonia are stained while others such as breast ductal epithelium, kidney tubular epithelium, endometrium, parathyroid and stomach chief cells are weakly stained. The antibody is reactive with benign and malignant histiocytic lesions such as sinus histiocytosis, dermatopathic lymphadenopathy, persistent generalized lymphadenopathy, tuberculosis, sarcoidosis, Gaucher′s disease, true histiocytic lymphomas, malignant histiocytosis and histiocytosis-X.

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