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M2011 Sigma

Melphalan

powder

Synonym: 4-[Bis(2-chloroethyl)amino]-L-phenylalanine, L-PAM, L-Phenylalanine mustard

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Description

Biochem/physiol Actions

Melphalan is an antineoplastic agent. It forms DNA intrastrand crosslinks by bifunctional alkylation in 5′-GGC sequences.

Packaging

1 g in glass bottle

100, 250 mg in glass bottle

Price and Availability


Flow Cytometry Instruments

All labs need water
Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN2811 - class 6.1 - PG 2 - RQ - Toxic solids, organic, n.o.s. HI: all
WGK Germany 
3
RTECS 
AY3675000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

DNA Damage and Repair

Damage to cellular DNA is involved in mutagenesis and the development of cancer. The DNA in a human cell undergoes several thousand to a million damaging events per day, generated by both external (e...
Keywords: AGE, Alkylations, Apoptosis, Biochemistry, Cancer, Carcinogens, Catalysis, Clinical, DNA replication, Deaminations, Degradations, Eliminations, Environmental, Enzymology, Gene expression, Genetic, Infrared spectroscopy, Metabolites, Methylations, Mutagens, Oncology, Oxidations, Polymorphisms, Rearrangements, Recombination, Substitutions, Transcription, transformation

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Peer-Reviewed Papers
15

References

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