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M2017 Sigma

Mazindol

≥98% (TLC), powder

Synonym: 5-(4-Chlorophenyl)-2,5-dihydro-3H-imidazo[2,1-a]isoindol-5-ol

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Properties

Related Categories Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents, Biogenic Amine Transport Inhibitors,
InChI Key   ZPXSCAKFGYXMGA-UHFFFAOYSA-N
assay   ≥98% (TLC)
form   powder
drug control   USDEA Schedule IV; Home Office Schedule 3; psychotrope; kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)
color   white
solubility   DMSO: soluble10 mg/mL
originator   Wyeth
Gene Information   human ... SLC6A2(6530), SLC6A3(6531), SLC6A4(6532)
rat ... Htr1a(24473), Htr2a(29595), Slc6a3(24898), Slc6a4(25553)

Description

Biochem/physiol Actions

Anorectic agent; inhibits the dopamine, norepinephrine and serotonin transporters with Kis of 27.6 nM, 3.2 nM, and 153 nM, respectively.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGII
WGK Germany 
3
RTECS 
NI2975000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

History of Biogenic Amine Use for Treating Obesity

The discovery of ephedrine (Product No. E2750) in the 1930s led to the synthesis of amphetamines. Initially utilized as stimulants, they were soon shown to exhibit food intake and appetite suppressin...
Keywords: Obesity

Peer-Reviewed Papers
15

References

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