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M2295 Sigma

Myelin Basic Protein from guinea pig brain

≥80% (SDS-PAGE), lyophilized powder, from guinea pig brain

Synonym: MBP

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Description

Packaging

1, 5 mg in glass bottle

Quality

May contain traces of urea-glycine buffer salts.

Biochem/physiol Actions

Mutation of the myelin basic protein gene induces dysmyelination; used to induce experimental allergic encephalomyelitis.

Myelin basic protein (MBP) plays a vital role in formation of myelin sheath and is associated with the various neurological disorders. MBP function as an antigenic target in autoimmune disease experimental allergic encephalomyelitis (EAE). MBP plays an essential role in cytoskeletal turnover and membrane extension. Additionally, it is also involved in Fyn-mediated signaling pathways, sequestration of phosphoinositides and regulation of calcium homoeostasis. MBP functions as an in vitro substrate for mitogen-activated protein kinase (MAP) kinase and aids in the purification and functional studies of enzyme.

Principle

Used as a kinase substrate.

General description

Myelin Basic Protein (MBP) expressed in guinea pig brain contains 167 amino acids and has a molecular weight of 18,256Da.

Price and Availability


Amplified Detection

Making Headway

All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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