|Related Categories||Adhesion Molecules and Related Proteins, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,|
|solubility||DMSO: soluble38 mg/mL|
Blocker of gap junction channels Cx36 and Cx50.
Certificate of Analysis
Certificate of Origin
An in vivo drug screening model using glucose-6-phosphate dehydrogenase deficient mice to predict the hemolytic toxicity of 8-aminoquinolines. Zhang P, Gao X, Ishida H, et al. Am. J. Trop. Med. Hyg. 88(6), 1138-45, (2013)
Progressive Multifocal Leukoencephalopathy with Immune Reconstitution Inflammatory Syndrome (PML-IRIS): two case reports of successful treatment with mefloquine and a review of the literature. Young BE, Yeo TR, Lim HT, et al. Ann. Acad. Med. Singapore 41(12), 620-4, (2012)
The anti-malarial drug Mefloquine disrupts central autonomic and respiratory control in the working heart brainstem preparation of the rat. Lall VK, Dutschmann M, Deuchars J, et al. J. Biomed. Sci. 19, 103, (2012)
Effect of single nucleotide polymorphisms in cytochrome P450 isoenzyme and N-acetyltransferase 2 genes on the metabolism of artemisinin-based combination therapies in malaria patients from Cambodia and Tanzania. Staehli Hodel EM, Csajka C, Ariey F, et al. Antimicrob. Agents Chemother. 57(2), 950-8, (2013)
The design, synthesis, in silico ADME profiling, antiplasmodial and antimycobacterial evaluation of new arylamino quinoline derivatives. Tukulula M, Little S, Gut J, et al. Eur. J. Med. Chem. 57, 259-67, (2012)
Favourable outcome of progressive multifocal leukoencephalopathy with mefloquine treatment in combination with antiretroviral therapy in an HIV-infected patient. Adachi E, Koibuchi T, Imai K, et al. Int. J. STD AIDS 23(8), 603-5, (2012)
Efficacy and tolerability of a new formulation of artesunate-mefloquine for the treatment of uncomplicated malaria in adult in Senegal: open randomized trial. Tine RC, Faye B, Sylla K, et al. Malaria Journal 11, 416, (2012)
Efficacy of dihydroartemisinin-piperaquine for treatment of uncomplicated Plasmodium falciparum and Plasmodium vivax in Cambodia, 2008 to 2010. Leang R, Barrette A, Bouth DM, et al. Antimicrob. Agents Chemother. 57(2), 818-26, (2013)
Failure of mefloquine therapy in progressive multifocal leukoencephalopathy: report of two Japanese patients without human immunodeficiency virus infection. Kobayashi Z, Akaza M, Numasawa Y, et al. J. Neurol. Sci. 324(1-2), 190-4, (2013)
Efficacy of mefloquine intermittent preventive treatment in pregnancy against Schistosoma haematobium infection in Gabon: a nested randomized controlled assessor-blinded clinical trial. Basra A, Mombo-Ngoma G, Melser MC, et al. Clin. Infect. Dis. 56(6), e68-75, (2013)
Cell type-specific, presynaptic LTP of inhibitory synapses on fast-spiking GABAergic neurons in the mouse visual cortex. Sarihi A, Mirnajafi-Zadeh J, Jiang B, et al. J. Neurosci. 32(38), 13189-99, (2012)
Artemisinin resistance containment project in Thailand. II: Responses to mefloquine-artesunate combination therapy among falciparum malaria patients in provinces bordering Cambodia. Satimai W, Sudathip P, Vijaykadga S, et al. Malaria Journal 11, 300, (2012)
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