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M2420 Sigma

Monoclonal Anti-Monocyte Chemotactic Protein-1 antibody produced in mouse

clone 24822, purified immunoglobulin, lyophilized powder

Synonym: Anti-CCL2, Anti-MCP-1

Description

Immunogen

recombinant human MCP-1/CCL2 expressed in E. coli.

General description

Monocyte Chemotactic Protein-1 (MCP-1) is a chemotactic factor that belongs to CC chemokine family and can attract basophils and monocytes but not eosinophils or neutrophils. It is produced in keratinocytes, fibroblasts, hepatoma cells and Type II pneumocytes in response to IL-1. It has a crucial role in recruiting immune cells to the site of antigens as well as behaves as an inflammatory mediator which stimulates the directional migration of T cells and monocytes. Monoclonal anti-Monocyte Chemotactic Protein-1 antibody is suitable for neutralization, in which it will not neutralize the activity of recombinant human MIP-1α, recombinant mouse MIP-1α or recombinant human RANTES. Mouse anti-Monocyte Chemotactic Protein-1 antibody reacts specifically with human MCP-1/CCL2.

Physical form

Lyophilized from a 0.2 μm solution in phosphate buffered saline containing carbohydrates.

Specificity

The antibody will neutralize the biological activity of recombinant human MCP-1.This antibody does not exhibit cross-reactivity with recombinant human RANTES, recombinant human MIP-1α, or recombinant mouse MIP-1α..

Preparation Note

Purified using protein A.

Application

Monoclonal anti-Monocyte Chemotactic Protein-1 antibody can be used in western blotting.

Price and Availability


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