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M258 Sigma

MARC from mouse

>97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, cell culture tested

Synonym: MCP-3

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Chemokines, Cytokines and Growth Factors, Cytokines, Growth Factors and Hormones,
recombinant   expressed in E. coli
assay   >97% (SDS-PAGE)
form   lyophilized powder
impurities   endotoxin, tested
suitability   cell culture tested
storage temp.   −20°C
Gene Information   mouse ... Ccl7(20306)

Description

Analysis Note

The biological activity is measured by its ability to chemoattract 2-day cultured human monocytes.

Physical form

Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% trifluoroacetic acid containing 0.5 mg bovine serum albumin.

Biochem/physiol Actions

MARC, a member of the β (CC) chemokine family of inflammatory and immunoregulatory cytokines, is a monocyte and T lymphocyte chemoattractant. MARC may be the mouse homolog of the human MCP-3 (monocyte chemotactic protein 3) gene.

MARC, a member of the β (CC) chemokine family of inflammatory and immunoregulatory cytokines, is a monocyte and T lymphocyte chemoattractant. MARC may be the mouse homolog of the human MCP-3 (monocyte chemotactic protein 3) gene. MARC/MCP-3 expression has also been detected during murine experimental allergic encephalomyelitis in the spinal cord and in LPS-stimulated murine WEHI -3 cells and Swiss 3T3 cells where MARC expression is glucocorticoid-attenuated. Mouse CCR-2 binds JE/MCP-1 with high affinity and MARC/MCP-3 with lower affinity.

Price and Availability


All labs need water
Safety & Documentation

Safety Information

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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