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M265 Sigma

Anti-Glutamate Receptor NMDAR2B (NR2B) antibody produced in rabbit

affinity isolated antibody, lyophilized powder

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Neurotransmission, Antibodies to Glutamate Receptors,
species reactivity   rat, mouse, human
application(s)   immunohistochemistry (frozen sections): 1:1,000
  immunoprecipitation: 3 μL using 200 μg of rat brain
  western blot: 1 μg/mL using 35S-Protein A (with ECL dilutions may be higher)
clone   polyclonal
antibody form   affinity isolated antibody
form   lyophilized powder
mol wt   antigen mol wt 180 kDa
storage temp.   −20°C
Gene Information   human ... GRIN2B(2904)
mouse ... Grin2b(14812)
rat ... Grin2b(24410)
conjugate   unconjugated

Description

Immunogen

C-terminal portion of NR2B (amino acids 984-1104).

General description

The functional N-Methyl-D-Aspartate (NMDA) receptor complex consists of a NMDAR1 (NR1) subunit and atleast one NMDAR2 subunit ranging from NR2A-NR2D. These receptor complexes have been implicated in cochlear functions and neuronal plasticity. The C-terminal end of NR2B receptor may regulate synaptic localization 1,2,3
Anti-Glutamate Receptor NMDAR2B (NR2B) antibody is specific for NR2B subunit in mice, rats and humans. This antibody does not react with NR2A or NR2C subunits. The labeling of NR2B subunit by immunoblotting is blocked by the preadsorption of the antibody with the immunogen.

Physical form

Lyophilized from ammonium bicarbonate (5 mM).

Application

Anti-Glutamate Receptor NMDAR2B (NR2B) antibody is suitable for use in immunohistochemistry (1:1,000 dilution, using frozen sections), immunoprecipitation (3 μL using 200 μg of rat brain), and indirect ELISA. The antibody may also be used for western blot (1 μg/mL using (35S)-Protein A) and immunoblot (180 kDa).

Packaging

10 μg in serum bottle

Price and Availability


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