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  • M2672 - (±)-α-Methyl-(4-tetrazolylphenyl)glycine

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M2672 Sigma

(±)-α-Methyl-(4-tetrazolylphenyl)glycine

  • CAS Number 169209-66-9

  • Empirical Formula (Hill Notation) C10H11N5O2

  • Molecular Weight 233.23

  •  MDL number MFCD00672653

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Related Categories Biochemicals and Reagents, Enzyme Inhibitors, Enzyme Inhibitors by Type, Enzymes, Inhibitors, and Substrates, Substrate Analogs More...
InChI Key   PUQSGMIEFYCTSW-UHFFFAOYSA-N
storage temp.   2-8°C

Description

Biochem/physiol Actions

(±)-α-Methyl-(4-tetrazolylphenyl)glycine (MTPG) was used in rat models of cerebral ischemia to explore the role of group II metabotropic glutamate receptors mGluR2/3 in brain ischemia tolerance. MTPG inhibited the induction of ischemia tolerance indicating the involvement of mGluR2/3 in the induction of the protective mechanism.

Potent antagonist for (1S,3S)-ACPD-sensitive receptors; preference for GluR2 and GluR3 subtypes

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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