|Related Categories||Application Index, Bacteria, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes,|
|solubility||ethanol: soluble1 mg/mL|
Potent inhibitor of protein phosphatase Types 1 and 2A; has no effect on protein kinase. Hepatic tumor promoter in experimental animal model.1
Hepatotoxic cyclic heptapeptide.
Stock solutions can be diluted in 50 mM Tris-HCl, pH 7.0, containing 0.03% Brij 35; phosphatase inhibition will be retained for up to 1 month when stored at concentrations up to 0.01 nM.
Customers Also Viewed
≥90% (HPLC), solid
5 μg/mL in methanol (each), analytical standard, for environmental analysis
10 μg/mL in methanol, analytical standard, for environmental analysis
Certificate of Analysis
Certificate of Origin
|Precautionary statements||P261-P264-P280-P301 + P310-P302 + P350-P305 + P351 + P338|
|Personal Protective Equipment||Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges|
|Hazard Codes (Europe)||T+|
|Risk Statements (Europe)||26/27/28-36/37/38-43|
|Safety Statements (Europe)||26-36/37/39-45|
|RIDADR||UN 2811PIH 6.1 / PGI|
Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete. The expansion of the carcinogenesi...
BioFiles 2008, 3.5, 18.
Keywords: Acetylations, Adhesion, Alkylations, Apoptosis, Cancer, Carcinogens, Cell division, Cell proliferation, Cell signaling, DNA microarrays, Drug discovery, Environmental, Epigenetics, Gene expression, Genetic, Hormones, Metabolism, Methylations, Microarray Analysis, Mutagens, PAGE, Recombination, Reductions, Transcription, transformation
Phosphoprotein phosphatases, which hydrolyze the phosphoester bonds of phosphoserines, phosphothreonines or phosphotyrosines, play an essential role in signal transduction and actively contribute to ...
Keywords: Catalysis, Cloning, Gene expression, Neurotransmitters, Phosphorylations, Transduction
1. Chronic Microcystin Exposure Induces Hepatocyte Proliferation with Increased Expression of Mitotic and Cyclin-associated Genes in P53-deficient Mice. Clark, S. P., et al. Toxicol. Pathol., (2008)
Histological, cytological and biochemical alterations induced by microcystin-LR and cylindrospermopsin in white mustard (Sinapis alba L.) seedlings. Máthé C, Vasas G, Borbély G, et al. Acta Biol. Hung. 64(1), 71-85, (2013)
Electrochemical immunosensor for ultrasensitive detection of microcystin-LR based on graphene-gold nanocomposite/functional conducting polymer/gold nanoparticle/ionic liquid composite film with electrodeposition. Ruiyi L, Qianfang X, Zaijun L, et al. Biosens. Bioelectron. 44, 235-40, (2013)
Combined exposure to 3-chloro-4-dichloromethyl-5-hydroxy-2(5H)-furanone and microsytin-LR increases genotoxicity in Chinese hamster ovary cells through oxidative stress. Wang S, Tian D, Zheng W, et al. Environ. Sci. Technol. 47(3), 1678-87, (2013)
Toxic risk associated with sporadic occurrences of Microcystis aeruginosa blooms from tidal rivers in marine and estuarine ecosystems and its impact on Artemia franciscana nauplii populations. D'ors A, Bartolomé MC, and Sánchez-Fortún S Chemosphere 90(7), 2187-92, (2013)
Mn-doped carbon xerogels as catalyst in the removal of microcystin-LR by water-surface discharge plasma. Xin Q, Zhang Y, and Wu KB J. Environ. Sci. Health. A. Tox. Hazard. Subst. Environ. Eng. 48(3), 293-9, (2013)
A graphene and multienzyme functionalized carbon nanosphere-based electrochemical immunosensor for microcystin-LR detection. Zhao H, Tian J, and Quan X Colloids Surf. B Biointerfaces 103, 38-44, (2013)
Bioacumulation of cyanotoxins in Hypophthalmichthys molitrix (silver carp) in Paranoá Lake, Brasilia-DF, Brazil. Oliveira NB, Schwartz CA, Bloch C, et al. Bull. Environ. Contam. Toxicol. 90(3), 308-13, (2013)
Colloidal graphene as a transducer in homogeneous fluorescence-based immunosensor for rapid and sensitive analysis of microcystin-LR. Liu M, Zhao H, Chen S, et al. Environ. Sci. Technol. 46(22), 12567-74, (2012)
Microcystin-LR promotes melanoma cell invasion and enhances matrix metalloproteinase-2/-9 expression mediated by NF-κB activation. Zhang XX, Fu Z, Zhang Z, et al. Environ. Sci. Technol. 46(20), 11319-26, (2012)
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Need larger quantities for your development, manufacturing or research applications?