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M2912 Sigma

Microcystin LR from Microcystis aeruginosa

≥95% (HPLC), solid film

Synonym: 5-L-Arginine-microcystin LA

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Properties

assay   ≥95% (HPLC)
form   solid film
solubility   ethanol: 1 mg/mL
  DMSO: soluble
storage temp.   −20°C

Description

Biochem/physiol Actions

Potent inhibitor of protein phosphatase Types 1 and 2A; has no effect on protein kinase. Hepatic tumor promoter in experimental animal model.

Other Notes

Hepatotoxic cyclic heptapeptide.

Reconstitution

Stock solutions can be diluted in 50 mM Tris-HCl, pH 7.0, containing 0.03% Brij 35; phosphatase inhibition will be retained for up to 1 month when stored at concentrations up to 0.01 nM.

Price and Availability


Laboratory Gloves
Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
RIDADR 
UN 2811PIH 6.1 / PGI
WGK Germany 
3
RTECS 
GT2810000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Carcinogenesis and Epigenetics

Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete. The expansion of the carcinogenesi...
Vicki Caligur
BioFiles 2008, 3.5, 18.
Keywords: Acetylations, Adhesion, Alkylations, Apoptosis, Biofiles, Cancer, Carcinogens, Cell division, Cell proliferation, Cell signaling, DNA microarrays, Drug discovery, Environmental, Epigenetics, Events, Gene expression, Genetic, Hormones, Metabolism, Methylations, Microarray Analysis, Mutagens, PAGE, Recombination, Reductions, Sequences, Transcription, Type, transformation

Peer-Reviewed Papers
15

References

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