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M2949 Sigma

MDL 72527

≥98% (HPLC)

Synonym: CPC-200, MDL-72527DA, N,N′-Bis(2,3-butadienyl)-1,4-butanediamine dihydrochloride, N1,N4-Bis(2,3-butadienyl)-1,4-butanediamine hydrochloride

  • CAS Number 93565-01-6

  • Empirical Formula (Hill Notation) C12 H20 N2·2 HCl

  • Molecular Weight 265.22

  •  MDL number MFCD13152261

  •  PubChem Substance ID 329817958

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, M
InChI Key   ITVRWVVFVHINOH-UHFFFAOYSA-N
assay   ≥98% (HPLC)
form   powder
color   light yellow to light brown
solubility   H2O: soluble15 mg/mL, clear
storage temp.   room temp

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

MDL 72527is an inhibitor of polyamine oxidase (spermine oxidase SMO). It blocks the production of H2O2 and increases the cells survival. Polyamine catabolism is one of the major causes of the ROS production of prostate cells in general and androgen-induced enhancement of ROS in androgen-dependent CaP cells in particular. Reports suggest that androgen stimulation of prostate cancer results in accumulation of ROS, which lead to progression of cancer, such progression is control by MDL 72527.

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Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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