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M3047 Sigma

Mizoribine

≥98% (TLC)

Synonym: N′-(β-D-Ribofuranosyl)-5-hydroxy­imida­zole-4-carboxamide

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Description

Packaging

10 mg in poly bottle

25 mg in glass bottle

Biochem/physiol Actions

Mizoribine is an imidazole nucleoside possessing strong immunosuppressive properties. Selectively blocks T-cell proliferation response to mitogenic and allo-antigenic stimulation. Mizoribine blocks the movement of T cells from G to S phase. In addition, it significantly decreases the number of B cells at the S, G, and M phases. Mizoribine inhibits de novo synthesis of nucleotides by inhibition of inosine monophosphate dehydrogenase. The resulting nucleotide depletion inhibits DNA synthesis.

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Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
NI3980000
Protocols & Articles
Peer-Reviewed Papers
15

References

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