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M3512 Sigma

(±)-Miconazole nitrate salt

imidazole antibiotic

Synonym: 1-(2,4-Dichloro-β-[(2,4-dichlorobenzyl)oxy]phenethyl)imidazole



Miconazole is an imidazole antifungal agent that is used topically and by intravenous infusion. It is used to inhibit cytochrome P450 1 and to study automated luminescence-based cytochrome P450 profiling2.

Biochem/physiol Actions

Miconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary for ergosterol biosynthesis. The inhibition of ergosterol results in increased cellular permeability causing leakage of cellular contents. Miconazole may also inhibit endogenous respiration, interact with phospholipids in the cell membrane, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and interfere with triglyceride and phospholipid biosynthesis.

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Suggested Laboratory Gloves

Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.

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(±)-Miconazole nitrate salt

pharamaceutical secondard standard: traceable to UPS, PhEur and BP


European Pharmacopoeia (EP) Reference Standard

Miconazole nitrate

United States Pharmacopeia (USP) Reference Standard

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