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  • M3787 - Anti-MAP Kinase Phosphatase-1 (MKP-1) antibody produced in rabbit

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M3787 Sigma

Anti-MAP Kinase Phosphatase-1 (MKP-1) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Kinase/Phosphatase Biology, M1-MAR,
species reactivity   human
application(s)   microarray: suitable
  western blot: 1:5,000 using TPA-induced A431 whole cell extract
clone   polyclonal
antibody form   IgG fraction of antiserum
form   buffered aqueous solution
mol wt   antigen mol wt 39 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... DUSP1(1843)
mouse ... Dusp1(19252)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

Synthetic peptide corresponding to amino acids 87-99 of mouse MAP kinase phosphatase-1, coupled to KLH.

General description

Map kinase phosphatase-1 (MKP-1) is a protein that belongs to protein-tyrosine phosphatase family. It has a pivotal role in inhibiting p38 and subsequent destabilisation of pro-inflammatory mRNAs by GCs. It also has a crucial role in regulating MAP kinase and can inhibit fibroblast proliferation due to overexpression. Anti-MAP kinase phosphatase-1 (MKP-1) antibody can be used to study the differential tissue expression, specific activation requirements and for intracellular localization of MAP kinase phosphatases in normal and neoplastic cells and tissues. Rabbit anti-MAP kinase phosphatase-1 (MKP-1) antibody reacts specifically with MAP kinase phosphatase-1 (39 kD protein). The product has also shown reactivity for human.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Application

Anti-MAP kinase phosphatase-1 (MKP-1) antibody can be used in western blotting (diluted-1:5,000) using TPA-induced A431 whole cell extract. It can also be used in microarray.

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