|Related Categories||Antibiotic powders, Antibiotics, Antibiotics A to Z, Antibiotics G-M, Antibiotics by Application,|
|solubility||H2O: soluble4 mL/vial, clear to slightly hazy, blue to purple (Stock solutions should be filter sterilized and stored at 2-8 °C in the dark.)|
|suitability||suitable for cell culture|
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Mitomycin C is used to generate mitotically inactive feeder cells used in cell culture systems, such as mitotically inactive fibroblast used in embryonic stem cell (ESC) systems.
Inhibitor of DNA synthesis, nuclear division, and cancer cells. Antibacterial to gram positive, gram negative, acid-fast bacilli.
Mitomycin C is an anti-neoplastic antibiotic, DNA inter-strand, cross-linking, alkylating agent that targets guanine nucleoside in the sequence 5′CpG-3′. It produces oxygen radicals and is preferentially toxic to hypoxic cells.
Vial contains 2 mg mitomycin C and 48 mg NaCl.
Certificate of Analysis
Certificate of Origin
Effect of mitomycin-C on human foreskin fibroblasts used as feeders in human embryonic stem cells: immunocytochemistry MIB1 score and DNA ploidy and apoptosis evaluated by flow cytometry Nieto A, et al. Cell Biol. Int. 31, 269-278, (2007)
Interspecies somatic cell nucleus transfer with porcine oocytes as recipients: A novel bioassay system for assessing the competence of canine somatic cells to develop into embryos. Sugimura, S., et al. Ther. Drug Monit. 72, 549-59, (2009)
Synthesis of new pyrazolo[5,1-c][1,2,4] benzotriazines, pyrazolo[5,1-c]pyrido[4,3-e][1,2,4] triazines and their open analogues as cytotoxic agents in normoxic and hypoxic conditions. Giovanna Ciciani et al Bioorg. Med. Chem. 16, 9409-19, (2008)
Possible anticancer agents: QSAR analogs of glutamamide: synthesis and pharmacological activity of 1,5-N,N'-disubstituted-2-(substituted benzenesulphonyl) glutamamides. Soma Samanta et al Eur. J. Med. Chem. 44, 70-82, (2009)
New pterocarpanquinones: synthesis, antineoplasic activity on cultured human malignant cell lines and TNF-alpha modulation in human PBMC cells. Chaquip D Netto et al Bioorg. Med. Chem. 18, 1610-6, (2010)
Synthesis, pharmacological activity and comparative QSAR modeling of 1,5-N,N'-substituted-2-(substituted naphthalenesulphonyl) glutamamides as possible anticancer agents. Amit Kumar Halder et al Eur. J. Med. Chem. 45, 1760-71, (2010)
Synthesis and toxicity towards normal and cancer cell lines of benzimidazolequinones containing fused aromatic rings and 2-aromatic ring substituents E. Moriarty, et al. Eur. J. Med. Chem. 45, 3762-3769, (2010)
2,5-Disubstituted-1,3,4-oxadiazoles/thiadiazole as surface recognition moiety: design and synthesis of novel hydroxamic acid based histone deacetylase inhibitors. Harish Rajak et al Bioorg. Med. Chem. Lett. 21, 5735-8, (2011)
2-Anilinonicotinyl linked 2-aminobenzothiazoles and [1,2,4]triazolo[1,5-b] [1,2,4]benzothiadiazine conjugates as potential mitochondrial apoptotic inducers. Ahmed Kamal et al Bioorg. Med. Chem. 19, 7136-50, (2011)
Synthesis, antiproliferative activity and genotoxicity of novel anthracene-containing aminophosphonates and a new anthracene-derived Schiff base. I Kraicheva et al Bioorg. Med. Chem. 20, 117-24, (2012)
Y. Hashimoto et al. Acc. Chem. Res. 17, 403, (1984)
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