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M4940 Sigma

MMP Control-6

buffered aqueous solution

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Description

Analysis Note

MMP/TIMP Molecular weights:
MMP-No., Mr latent/active*
MMP-1, 52,000 / 43,000
MMP-2, 71,000 / 62,000
MMP-3, 52,000 / 43,000
MMP-7, 28,000 / 19,000
MMP-8, 51,000 / 42,000
MMP-9, 76,000 / 67,000
MMP-10, 52,000 / 44,000
MMP-11, 51,000 / 46,000
MMP-12, 52,000 / 20,000
MMP-13, 52,000 / 42,000
MMP-14, 64,000 / 54,000
MMP-15, 71,000 / 61,000
MMP-16, 66,000 / 56,000
MMP-17, 62,000 / 51,000
MMP-18, 53,000 / 42,000
*Mr is based on the cDNA sequence, excluding signal peptide. Some MMPs may have glycosylated forms of higher Mr . Thus, for example:
MMP-8 in neutrophils, but not other tissues, has Mr = 85,000 / 64,000.
MMP-9 has Mr = 92,000 / 84,000.
MMP-11 (stromelysin 3) has Mr = 64,000 / 46,000.
Human MMP-13 has a latent form of 65,000.
TIMP-1 has a molecular mass by sequencing of 20.6 kDa and a glycosylated mass of 28.5 kDa.
TIMP-2 has a molecular mass by sequencing of 21.5 kDa.
Matrix Metalloproteinases and TIMPS, Woessner, J.F., and Nagase, H., Oxford University Press (Oxford, UK: 2000) pp. 2 and 9.

Recommended use for immunoblotting: mix 1:1 with 2X SDS-PAGE buffer and apply 20-40 μl per lane.

Application

Used as a qualitative positive control in immunoblotting for MMP-7.

General description

Concentrated, serum-free, cell culture media from human fibroblasts containing human matrilysin (MMP-7) as well as other MMPs and TIMPs.

Physical form

Solution in 0.01 M phosphate buffered saline.

Price and Availability


All labs need water

Biomedical Applications
Safety & Documentation

Safety Information

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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