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  • M5184 - Anti-Matrix Metalloproteinase-18, N-Terminal antibody produced in rabbit

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M5184 Sigma

Anti-Matrix Metalloproteinase-18, N-Terminal antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution

Synonym: Anti-Xenopus collagenase, Anti-MMP-18, Anti-MMP-21-A, Anti-XMMP

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Extracellular Matrix, Antibodies to Matrix Metalloproteinases and TIMPs,
species reactivity   Xenopus
application(s)   immunohistochemistry (frozen sections): suitable
  immunoprecipitation: suitable
  indirect ELISA: suitable
  western blot: 1:1,000
clone   polyclonal
concentration   ~1 mg/mL
antibody form   affinity isolated antibody
form   buffered aqueous glycerol solution
shipped in   wet ice
storage temp.   −20°C
Gene Information   Xenopus laevis ... mmp21-A(378572)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to the N-terminal of Xenopus matrix metalloproteinase-18 (Xenopus collagenase, collagenase-4)

General description

Matrix metalloproteinase-18 (MMP-18) is an interstitial collagenase which possesses a special insertion domain of 37 amino acids. It is made up of around 626 amino acids. During metamorphosis, MMP-18 is controlled in tissue-dependent way.

Physical form

Solution in phosphate buffered saline, pH 7.4, containing 50% glycerol and 15 mM sodium azide

Specificity

Reacts with reduced and non-reduced MMP-18. Recognizes the pro-form and the active forms of MMP-18. By immunoblotting, the antibody reacts with bands at 53 kDa and 51 kDa (proform).

Biochem/physiol Actions

Matrix metalloproteinase-18 (MMP-18) plays an important role in the development of Xenopus laevis.

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