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  • M5434 - Anti-Matrix Metalloproteinase-19, Hinge Region antibody produced in rabbit

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M5434 Sigma

Anti-Matrix Metalloproteinase-19, Hinge Region antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution

Synonym: Anti-MMP-19

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Extracellular Matrix, Antibodies to Matrix Metalloproteinases and TIMPs,
species reactivity   human
application(s)   immunohistochemistry (frozen sections): suitable
  immunoprecipitation: suitable
  indirect ELISA: suitable
  western blot: 1:1,000
clone   polyclonal
concentration   ~1 mg/mL
antibody form   affinity isolated antibody
form   buffered aqueous glycerol solution
mol wt   antigen (active form) mol wt 45 kDa
  antigen (pro-form) mol wt 58 kDa
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... MMP19(4327)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to the hinge region of human matrix metalloproteinase-19 (RASI).

General description

Matrix metalloproteinase-19 (MMP19) is an endopeptidase which depends on zinc for activation. It contains a signal sequence, a propeptide domain, a catalytic domain and a carboxy-terminal fragment. The gene encoding this protein is located on human chromosome 12q14.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 50% glycerol and 15 mM sodium azide.

Specificity

Reacts with reduced and non-reduced MMP-19. Recognizes the pro-form and active forms of MMP-19, as well as a series of further cleaved active forms.

Biochem/physiol Actions

Matrix metalloproteinase-19 (MMP-19) may have a role in arthritis and takes part in the advancement of lung cancer.

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