|Related Categories||Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Excitatory Amino Acids,|
|color||off-white to light tan|
|solubility||DMSO: soluble10 mg/mL, clear|
|storage temp.||room temp|
human ... GRIN2B(2904), GRM5(2915)|
rat ... Grm5(24418)
Highly selective, non-competitive mGluR5 metabotropic glutamate receptor antagonist.
Certificate of Analysis
The existence of G protein-coupled glutamate receptors (also called “metabotropic” glutamate or mGlu’s), belonging to the seven transmembrane spanning superfamily of receptors, was shown definitively...
Keywords: Atomic absorption spectroscopy, Cloning, Gene expression, Ligands, Neurotransmission, Neurotransmitters, Obesity, Schizophrenia, Transduction
Aldrich Chemistry lists over 600 alkyne building blocks, including a wide array of propargyl alcohols, acetylenic boron reagents, and halogenated substrates for cross-coupling. Additionally, many of ...
Keywords: Building blocks, Coupling reactions, Cross couplings
Antagonism of the mGlu5 agonist 2-chloro-5-hydroxyphenylglycine by the novel selective mGlu5 antagonist 6-methyl-2-(phenylethynyl)-pyridine (MPEP) in the thalamus. Salt, T.E. et al. Br. J. Pharmacol. 127, 1057-1059, (1999)
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