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M5518 Sigma

Mezerein

from Daphne mezereum, ≥97% (HPLC)

Synonym: 12β-[(E,E)-5-Phenyl-2,4-pentadienoyloxy]daphnetoxin

  • CAS Number 34807-41-5

  • Empirical Formula (Hill Notation) C38H38O10

  • Molecular Weight 654.70

  •  Beilstein Registry Number 1675867

  •  MDL number MFCD00135953

  •  PubChem Substance ID 24897019

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Properties

Related Categories Cancer Research, Cell Biology, Cell Signaling and Neuroscience, Kinase/Phosphatase Biology, Protein Kinase Activators,
biological source   from Daphne mezereum
InChI Key   DLEDLHFNQDHEOJ-WNRHQEOASA-N
assay   ≥97% (HPLC)
storage temp.   −20°C

Description

Biochem/physiol Actions

Potent second stage tumor promotor and inflammatory agent; activates protein kinase C at nanomolar concentrations.

Other Notes

Phorbol ester analog from the plant Daphne mezereum.

Price and Availability


All labs need water
Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
HB5425500

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Carcinogenesis and Epigenetics

Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete. The expansion of the carcinogenesi...
Vicki Caligur
BioFiles 2008, 3.5, 18.
Keywords: Acetylations, Adhesion, Alkylations, Apoptosis, Biofiles, Cancer, Carcinogens, Cell division, Cell proliferation, Cell signaling, DNA microarrays, Drug discovery, Environmental, Epigenetics, Events, Gene expression, Genetic, Hormones, Metabolism, Methylations, Microarray Analysis, Mutagens, PAGE, Recombination, Reductions, Sequences, Transcription, Type, transformation

Peer-Reviewed Papers
15

References

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