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M5539 Sigma

Anti-Macrophage Inflammatory Protein-2 antibody produced in goat

affinity isolated antibody, lyophilized powder

Synonym: Anti-MIP-2

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Chemokines, Antibodies to Cytokines and Growth Factors,
species reactivity   mouse
application(s)   indirect ELISA: suitable
  neutralization: suitable
  western blot: suitable
clone   polyclonal
antibody form   affinity isolated antibody
form   lyophilized powder
storage temp.   −20°C
Gene Information   mouse ... Cxcl2(20310)
biological source   goat
conjugate   unconjugated

Description

Immunogen

recombinant mouse MIP-2 expressed in E. coli.

General description

Macrophage Inflammatory Protein-2 belongs to the C-X-C family of chemokines and acts as chemoattractant for neutrophils. MIP-2 was originally identified as heparin-binding protein secreted in response to endotoxin. This chemokine acts majorly to induce influx of neutrophils following infection by pneumococci, hypersensitive reaction to viral antigen and inflammation due to glomerular nephritis. Pulmonary introduction of LPS results in rapid increase in the levels of MIP-2 producing inflammation. Anti-Macrophage Inflammatory Protein-2 antibody is specific for mouse MIP-2.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Specificity

The antibody shows <5% cross-reactivity with recombinant human GROα, recombinant human GROβ and recombinant human GROγ.

Application

Anti-Macrophage Inflammatory Protein-2 antibody may be used for ELISA at a working antibody concentration of 0.5-1.0 μg/ml. For immunoblotting, antibody concentration of 0.1-0.2 μg/ml is recommended. The antibody is suitable for neutralization reactions.

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Safety Information

Personal Protective Equipment  Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RIDADR  NONH for all modes of transport
WGK Germany  3
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Peer-Reviewed Papers
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References

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