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M5683 Sigma

Anti-MADD antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym: Anti-DENN, Anti-MAP Kinase-Activating Death Domain

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Apoptosis, Antibodies for Cell Biology, Antibodies to Adaptors,
species reactivity   human, mouse
does not react with   rat
application(s)   microarray: suitable
  western blot: 2 μg/mL using human HeLa or mouse NIH3T3 cell extract
clone   polyclonal
antibody form   IgG fraction of antiserum
form   buffered aqueous solution
mol wt   antigen mol wt 200-220 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... MADD(8567)
mouse ... Madd(228355)
rat ... Madd(94193)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to amino acids 1570-1588 of human MADD. The sequence contains one amino acid substitution with rat GDP/GTP exchange proten Rab3-GEP

General description

MAP kinase activating death domain (MADD) is an 183kDa protein expressed in normal cells as well as in malignant tumors of the lung and ovary. It contains 1647 amino acids and the gene encoding it is localized on human chromosome 11p11.21-p11.22.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide

Specificity

The antibody reacts with human MADD (MAP kinase-Activating Death Domain). The protein is also known as DENN (Differentially Expressed in Normal and Neoplastic cells).

Biochem/physiol Actions

MAP kinase activating death domain (MADD) interacts with the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor. It plays an important role as a downstream regulator of the apoptosis pathways mediated by TRAIL.

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Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  nwg
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