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M5808 Sigma

Anti-Matrix Metalloproteinase-14, N-Terminal antibody produced in rabbit

0.5 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym: Anti-MMP-14

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies against Adhesion, Attachment, and Matrix Factors, Antibodies for Cell Biology, Antibodies to Extracellular Matrix,
species reactivity   human
application(s)   immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100 using human cancer tissue
  indirect ELISA: 1:1,000
  western blot: 1:100-1:500 using A375 lysate
clone   polyclonal
concentration   0.5 mg/mL
antibody form   affinity isolated antibody
form   buffered aqueous solution
mol wt   antigen mol wt ~65 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... MMP14(4323)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to amino acids 185-299 in the N-terminal region of human matrix metalloproteinase-14 (membrane-type matrix metalloproteinase-1), conjugated to KLH.

General description

Matrix metalloproteinase-14 (MMP-14) is a collagenase localized to the cell membrane. The gene encoding it is present on human chromosome 14.

Physical form

Solution in phosphate buffered saline containing 0.09% (w/v) sodium azide.

Application

Anti-matrix metalloproteinase-14, N-terminal antibody produced in rabbit has been used for western blotting at a dilution of 1:100.

Biochem/physiol Actions

Matrix metalloproteinase-14 (MMP-14) aids in the migration of leukocytes and breaks down collagen. Migration of cells through the extracellular matrix is also mediated by it. MMP-14 has been shown to be associated with tuberculosis and glioma.

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