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M5917 Sigma

Anti-Macrophage Inflammatory Protein-1β antibody produced in goat

IgG fraction of antiserum, lyophilized powder

Synonym: Anti-MIP-1β

Description

Immunogen

recombinant mouse MIP-1β expressed in E. coli.

General description

Macrophage Inflammatory Protein-1-β is a member of the chemokine family and is produced in macrophages when stimulated by bacterial endotoxins. Anti-macrophage inflammatory protein-1β antibody can be used in immunoblotting. Goat anti-macrophage inflammatory protein-1β antibody reacts specifically with recombinant mouse MIP-1 β but does not react with recombinant human MIP-1 β or recombinant mouse or human MIP-1α.

Macrophage inflammatory protein-1 β (CCL4) belongs to a family of MIP-1 chemotactic cytokines (CC). The other members are CCL3 (MIP-1α), CCL9/10 (MIP-1δ) and CCL15 (MIP-1γ). The members of MIP-1 family have the ability to self-associate and form aggregates of high molecular weight. The self- aggregation is a reversible process and occurs in T cells, B cells and macrophages in response to inflammatory factors and bacterial endotoxins. This response results in inflammation and platelet degranulation
Anti-Macrophage Inflammatory Protein-1β antibody is specific for mouse MIP-1 β. It shows less than 2% cross reactivity with recombinant mouse MIP-1α, recombinant human MIP-1α and MIP-1β.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline, containing 5% trehalose

Preparation Note

Purified using protein G.

Application

Anti-Macrophage Inflammatory Protein-1β antibody may be for immunoblotting at a working concentration of 1.0 μg/ml. The antibody is suitable for neutralization reactions.

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