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  • M6057 - Anti-Matrix Metalloproteinase-12, Propeptide Region antibody produced in rabbit

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M6057 Sigma

Anti-Matrix Metalloproteinase-12, Propeptide Region antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution

Synonym: Anti-MMP-12

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Extracellular Matrix, Antibodies to Matrix Metalloproteinases and TIMPs,
species reactivity   human
application(s)   western blot: 1:3,000
clone   polyclonal
concentration   ~1 mg/mL
antibody form   affinity isolated antibody
form   buffered aqueous glycerol solution
mol wt   antigen mol wt 54 kDa
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... MMP12(4321)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to the propeptide region of human matrix metalloproteinase-12 (macrophage elastase).

General description

Matrix metalloproteinase-12 (MMP-12) is also called as macrophage metalloelastase and is secreted by inflammatory macrophages. It is synthesized as a zymogen and then activated by cleaving the propeptide domain. The MMP-12 gene is localized on human chromosome 11.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 50% glycerol and 15 mM sodium azide.

Specificity

The antibody recognizes only the latent form of MMP-12 and not the active forms. May be used to distinguish the zymogen and the activated enzyme.

Biochem/physiol Actions

Matrix metalloproteinase-12 (MMP-12) is involved in breaking down proteoglycans, collagen type IV and laminin. Its main substrate is elastin.

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WGK Germany  1
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