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M6060 Sigma

Molecular and Cellular Glycobiology

  •  ISBN-10 0-19-963806-3

  •  ISBN-13 978-0-19-963806-2

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publication info   M. Fukuda and O. Hindsgaul, ed., Oxford University Press, 2000, 272 pp., soft cover
mfr. no.   Oxford University Press

Description

General description

This book covers the recent progress in understanding the biological roles of carbohydrates. Emphasis is particularly placed on biological significance in immune cells, neural cells and cytoplasmic and nuclear proteins. It updates the knowledge of diseases caused by anomalies of carbohydrate biosynthesis and the animal models used to investigate the physiological roles of carbohydrates including carbohydrates attached to lipids and attempts to develop therapeutic agents based on carbohydrates.

Table of Contents

1. Cell surface carbohydrates: cell type-specific expression,, Minoru Fukuda
1. Introduction
2. Structure of N-glycans
3. Cell type-specific expression of N-glycans
4. O-glycans
5. Roles of cell surface carbohydrates
6. Glycobiology--new frontiers in cell and molecular biology
Acknowledgements
References
2. Carbohydrate recognition in leukocyte-endothelial cell
interactions,, Jonathon W. Homeister and John B. Lowe
1. Introduction
2. Oligosaccharides in lymphocyte homing
3. Oligosaccharide-dependent cell adhesion mediated by E-selectin
4. Oligosaccharide-dependent cell adhesion mediated by P-selectin
5. The sequential, multi-molecule model for leukocyte rolling,
adhesion and transmigration
Acknowledgements
References
3. Polysialic acid in neural cell development: roles, regulation
and mechanism,, Juan L. Bruses and Urs Rutishauser
1. Introduction
2. Biological roles of PSA
3. Regulation of PSA expression
4. Mechanisms of PSA action
5. Epilogue: the phylogeny of PSA-NCAM
References
4. Diseases with deficiencies in asparagine-linked glycosylation
A. Carbohydrate-deficient glycoprotein syndromes,, Harry Schachter
1. Introduction
2. Carbohydrate-deficient glycoprotein syndrome type I
3. Complex N-glycan synthesis within the Golgi apparatus
4. Carbohydrate-deficient glycoprotein syndrome tupe II (CDGII)
Acknowledgements
References
B. Congenital dyserythropoietic anemia tupe II,, Michiko N.
Fukuda
1. Introduction
2. Incidence and symptoms of HEMPAS
3. Biochemical characteristics of HEMPAS
4. Genetic analysis of HEMPAS
5. An animal model of HEMPAS
6. Why does a glycosylation defect result in anemia?
7. Unsolved problems
Acknowledgements
References
5. Functions of carbohydrates revealed by transgenic
technology,, Pamela Stanley
1. Introduction
2. The first mouse glycosylation mutants
3. Insights from transgenic mice that misexpress or overexpress a glycosyltransferase
4. Insights from mice with targeted gene mutations
5. Considerations for the next generation of mouse glycosylation mutants
6. Challenges for the new millennium
Acknowledgements
References
6. Functional significance of O-GlcNAc glycoproteins in the
nucleus and cytoplasm,, Lisa K. Kreppel and Gerald W. Hart
1. Introduction
2. Dynamic O-GlcNAcylation of proteins
3. Nuclear O-GlcNAcylation
4. Cytoplasmic O-GlcNAcylation
5. Conclusion
References
7. Roles of sphingolipids and glycosphingolipids in biological
membranes,, Yoshio Hirabayashi and Shinichi Ichikawa
1. Introduction
2. General features of membrane sphingolipids
3. Metabolism of complex sphingolipids
4. Roles of sphingolipids revealed by studies of mutant cells
5. Studies of sphingolipid function at the whole-animal level
6. Conclusion
References
8. Carbohydrates in medicine,, Joseph C. McAuliffe and Ole
Hindsgaul
1. Introduction
2. Why carbohydrates?
3. Targets of carbohydrate therapeutics
4. Examples of carbohydrate-based drugs
5. Examples of carbohydrate-modified drugs
6. Examples of carbohydrates in drug delivery
7. Conclusion
Acknowledgements
References
Index

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