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  • M6073 - Anti-MIB1 (N-terminal) antibody produced in rabbit

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M6073 Sigma

Anti-MIB1 (N-terminal) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym: Anti-DAPK-interacting protein 1, Anti-DIP-1, Anti-KIAA1323, Anti-Mindbomb homolog 1, Anti-Ubiquitin ligase mind bomb

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to E1,E2,E3 Ligase, Antibodies to Protein Degradation,
species reactivity   human
application(s)   western blot: 1:125-1:250 using lysates of HEK-293T cells over expressing MIB1
clone   polyclonal
antibody form   IgG fraction of antiserum
form   buffered aqueous solution
mol wt   antigen mol wt ~110 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... MIB1(57534)
mouse ... Mib1(225164)
rat ... Mib1(307594)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to amino acids 117-134 of human MIB1, conjugated to KLH. The corresponding sequence is identical in rat and mouse.

General description

Mindbomb homolog 1 (MIB1) is an ubiquitin ligase which possesses two substrate recognition domains at the carboxy terminal, ankyrin repeats and an amino terminal zinc finger domain.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Biochem/physiol Actions

Mindbomb homolog 1 (MIB1) aids in the ubiquitination and internalization of Notch ligands such as the protein Delta. It also acts as a positive regulator in the activation of nuclear factor-κB (NF-κB).

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Safety Information

Personal Protective Equipment  Eyeshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US)
RIDADR  NONH for all modes of transport
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Monoclonal and polyclonal primary antibodies are focused on cell biology, neurobiology and molecular biology. Secondary antibodies targeting multiple host’s IgG are conjugated to alkaline phosphatase...
Keywords: Amplification, Buffers, Cell biology, Enzyme-linked immunosorbent assay, Immunofluorescence, Immunohistochemistry, Inflammation, Molecular biology, Phosphorylations, Purification, Western blot

Peer-Reviewed Papers
15

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