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M6198 Sigma

Anti-MSX1 antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym: Anti-HOX7, Anti-HYD1, Anti-Homeobox 7, Anti-MSH homoebox 1

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies to Common Transcription Factors, Antibodies to Transcription Factors, Epigenetics,
species reactivity   human
application(s)   immunoprecipitation: 5-10 μg using lysates of HEK-293T over-expressing hMSX1.
  indirect immunofluorescence: 1-2 μg/mL using paraformaldehyde-fixed HEK-293T over expressing hMSX1 cells
  western blot: 0.5-1 μg/mL using lysates of HEK-293T over-expressing hMSX1.
clone   polyclonal
concentration   ~1.0 mg/mL
antibody form   affinity isolated antibody
form   buffered aqueous solution
mol wt   antigen mol wt ~31 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... MSX1(4487)
mouse ... Msx1(17701)
rat ... Msx1(81710)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to amino acids 122-137 of human MSX1 conjugated to KLH. The corresponding sequence in rat and mouse differs by two amino acids.

General description

Msh homeobox 1 (MSX1) possesses a MH4/homeodomain-DNA binding domain and is expressed in cranial neural crest cells. The gene encoding it is localized to chromosome 4p16 and contains two exons.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Biochem/physiol Actions

Msh homeobox 1 (MSX1) acts as a suppressor of mesenchymal cell differentiation and is important for hard tissue development. It activates bone morphogenetic protein 4 (BMP4), which has a role in tooth development. Mutations in the MSX1 gene have been associated with non-syndromic oligodontia.

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Personal Protective Equipment  Eyeshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US)
RIDADR  NONH for all modes of transport
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