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  • M6315 - Monoclonal Anti-Mismatch Repair Protein 2 antibody produced in mouse

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M6315 Sigma

Monoclonal Anti-Mismatch Repair Protein 2 antibody produced in mouse

~1 mg/mL, clone 2MSH01, tissue culture supernatant

Synonym: Anti-MSH2

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Gene Regulation, Antibodies to DNA Synthesis and Repair Enzymes, Cancer Research,
species reactivity   human
application(s)   immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25
clone   2MSH01, monoclonal
concentration   ~1 mg/mL
antibody form   tissue culture supernatant
isotype   IgG1
mol wt   antigen mol wt 102 kDa
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... MSH2(4436)
biological source   mouse
conjugate   unconjugated

Description

Immunogen

recombinant human mismatch repair protein 2 (MSH2).

General description

Mismatch repair protein 2 (MSH2) possesses four domains and belongs to the mismatch repair (MMR) gene family. The gene encoding this protein is localized on human chromosome 2p21.

Physical form

Contains 15 mM sodium azide.

Biochem/physiol Actions

Mismatch repair protein 2 (MSH2) plays a very important role in the DNA mismatch repair system. It repairs DNA damage which is induced by drugs. MSH2 dysfunction has been associated with nonpolyposis colorectal cancer (Lynch syndrome).

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Safety & Documentation

Safety Information

WGK Germany  -
Protocols & Articles

Articles

DNA Damage and Repair

Damage to cellular DNA is involved in mutagenesis and the development of cancer. The DNA in a human cell undergoes several thousand to a million damaging events per day, generated by both external (e...
Keywords: AGE, Alkylations, Apoptosis, Biochemistry, Cancer, Carcinogens, Catalysis, Clinical, DNA replication, Deaminations, Degradations, Eliminations, Environmental, Enzymology, Gene expression, Genetic, Infrared spectroscopy, Metabolites, Methylations, Mutagens, Oncology, Oxidations, Polymorphisms, Rearrangements, Recombination, Substitutions, Transcription, transformation

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Peer-Reviewed Papers
15

References

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