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M6792 Sigma

Anti-Macrophage Inflammatory Protein-1β antibody produced in goat

IgG fraction of antiserum, lyophilized powder

Synonym: Anti-MIP-1β

Description

Immunogen

recombinant human MIP-1β, expressed in Sf 21 insect cells.

General description

The antibody will neutralize the biological activity of recombinant human, but not mouse MIP-1β. It will not neutralize the biological activity of recombinant human or mouse MIP-1α.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Preparation Note

Purified using protein G.

Biochem/physiol Actions

Macrophage inflammatory protein-1β (CCL4) belongs to a family of MIP-1 chemotactic cytokines (CC). The members of MIP-1 family have the ability to self-associate and form aggregates of high molecular weight. The self- aggregation is a reversible process and occurs in T cells, B cells and macrophages in response to inflammatory factors and bacterial endotoxins. This response results in inflammation and platelet degranulation.

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