|Related Categories||Biochemicals and Reagents, Carbohydrate Library, Carbohydrates, Carbohydrates A to Z, Carbohydrates M-O,|
|impurities||≤1.0% total fructose 6-phosphate and glucose 6-phosphate|
Mannose is a monosaccharide.
10 mg in autosample vial
Mannose has been used in a study to assess the phenotyping of primary human microglia. 1 It has also been used in a study to investigate the identification of Anogeissus latifolia Wallich and analyze refined gum ghatti. 2
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. M6876.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
The DMAP interaction domain of UDP-GlcNAc:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase is a substrate recognition module. Qian Y, Flanagan-Steet H, van Meel E, et al. Proc. Natl. Acad. Sci. U. S. A. 110(25), 10246-51, (2013)
A bacterial glycosidase enables mannose-6-phosphate modification and improved cellular uptake of yeast-produced recombinant human lysosomal enzymes. Tiels P, Baranova E, Piens K, et al. Nat. Biotechnol. 30(12), 1225-31, (2012)
Latency-associated peptide of transforming growth factor-β1 is not subject to physiological mannose phosphorylation. Barnes J, Warejcka D, Simpliciano J, et al. J. Biol. Chem. 287(10), 7526-34, (2012)
Extensive mannose phosphorylation on leukemia inhibitory factor (LIF) controls its extracellular levels by multiple mechanisms. Barnes J, Lim JM, Godard A, et al. J. Biol. Chem. 286(28), 24855-64, (2011)
Identification of N-glycans displaying mannose-6-phosphate and their site of attachment on therapeutic enzymes for lysosomal storage disorder treatment. Bones J, Mittermayr S, McLoughlin N, et al. Anal. Chem. 83(13), 5344-52, (2011)
A zebrafish model of PMM2-CDG reveals altered neurogenesis and a substrate-accumulation mechanism for N-linked glycosylation deficiency. Cline A, Gao N, Flanagan-Steet H, et al. Mol. Biol. Cell 23(21), 4175-87, (2012)
Preparation of a mannose-6-phosphate glycan microarray through fluorescent derivatization, phosphorylation, and immobilization of natural high-mannose N-glycans and application in ligand identification of P-type lectins. Song X, Heimburg-Molinaro J, Dahms NM, et al. Methods Mol. Biol. 808, 137-48, (2012)
Polarizable water networks in ligand-metalloprotein recognition. Impact on the relative complexation energies of Zn-dependent phosphomannose isomerase with D-mannose 6-phosphate surrogates. Gresh N, de Courcy B, Piquemal JP, et al. J. Phys. Chem. B 115(25), 8304-16, (2011)
Isolation, purification, and biochemical characterization of two forms of lysosomal β-N-acetylhexosaminidase from the invertebrate Unio. Venugopal A and Sivakumar N Biosci. Biotechnol. Biochem. 77(3), 497-504, (2013)
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